buy viagra cialis online Drug Mechanism of Action 1 Clinical Applications 1 Acute Toxicity Delayed Toxicity Bortezomib Inhibitor of the 26S proteosome; results in down regulation of the NF ОєB signaling pathway Multiple myeloma, mantle cell lymphoma Nausea and vomiting, fever Peripheral sensory neuropathy, diarrhea, orthostatic hypotension, fever, pulmonary toxicity, reversible posterior leukoencephalopathy RPLS, congestive heart failure CHF, rare cases of QT prolongation Carfilzomib Inhibitor of the 26S proteosome; results in down regulation of the NF ОєB signaling pathway; maintains activity in bortezomib resistant tumors Multiple myeloma Fever Fatigue, cardiac toxicity with CHF and myocardial infarction, myelosuppression, pulmonary toxicity, hepatotoxicity, orthostatic hypotension Erlotinib Inhibits EGFR tyrosine kinase leading to inhibition of EGFR signaling Non small cell lung cancer, pancreatic cancer Diarrhea Skin rash, diarrhea, anorexia, interstitial lung disease Imatinib Inhibits Bcr Abl tyrosine kinase and other receptor tyrosine kinases, including PDGFR, and c kit CML, gastrointestinal stromal tumor GIST, Philadelphia chromosome positive ALL Nausea and vomiting Fluid retention with ankle and periorbital edema, diarrhea, myalgias, congestive heart failure Bosutinib Inhibits Bcr Abl tyrosine kinase and retains activity in imatinib resistant Bcr Abl mutations except for the T315I and V299L mutations
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buy viagra cialis online Drug Mechanism of Action 1 Clinical Applications 1 Acute Toxicity Delayed Toxicity Bortezomib Inhibitor of the 26S proteosome; results in down regulation of the NF ОєB signaling pathway Multiple myeloma, mantle cell lymphoma Nausea and vomiting, fever Peripheral sensory neuropathy, diarrhea, orthostatic hypotension, fever, pulmonary toxicity, reversible posterior leukoencephalopathy RPLS, congestive heart failure CHF, rare cases of QT prolongation Carfilzomib Inhibitor of the 26S proteosome; results in down regulation of the NF ОєB signaling pathway; maintains activity in bortezomib resistant tumors Multiple myeloma Fever Fatigue, cardiac toxicity with CHF and myocardial infarction, myelosuppression, pulmonary toxicity, hepatotoxicity, orthostatic hypotension Erlotinib Inhibits EGFR tyrosine kinase leading to inhibition of EGFR signaling Non small cell lung cancer, pancreatic cancer Diarrhea Skin rash, diarrhea, anorexia, interstitial lung disease Imatinib Inhibits Bcr Abl tyrosine kinase and other receptor tyrosine kinases, including PDGFR, and c kit CML, gastrointestinal stromal tumor GIST, Philadelphia chromosome positive ALL Nausea and vomiting Fluid retention with ankle and periorbital edema, diarrhea, myalgias, congestive heart failure Bosutinib Inhibits Bcr Abl tyrosine kinase and retains activity in imatinib resistant Bcr Abl mutations except for the T315I and V299L mutations